Genetic or Pharmacologic Nrf2 Activation Increases Proteinuria in Chronic Kidney Disease in Mice
Monday, August 24th, 2020
Brittney M. Rush, Corry D. Bondi, Sean D. Stocker, Kacie M. Barry,Sarah A. Small,Jason Ong, Soma Jobbagy, Donna B. Stolz, Sheldon I. Bastacky, Dionysios, V.
Drug Testing for Residual Progression of Diabetic Kidney Disease in Mice Beyond Therapy with Metformin, Ramipril, and Empagliflozin
Monday, July 13th, 2020
Manga Motrapu, Monika Katarzyna Swiderska, Irene Mesas, Julian Aurelio Marschner, Yutian Lei, Laura Martinez Valenzuela, Jia Fu, Kyung Lee, Maria Lucia Angelotti, Giulia Antonelli, Paola
Cardiac, renal and uterine hemodynamics changes throughout pregnancy in rats with a prolonged high fat diet from an early age
Monday, July 13th, 2020
Lidia Oltra, Virginia Reverte, Antonio Tapia, Juan M. Moreno, Francisco J. Salazar, Maria T. Llinas, “Cardiac, renal and uterine hemodynamics changes throughout pregnancy in rats
Discovery of diarylamides as novel orally active diuretics targeting urea transporters
Wednesday, June 24th, 2020
Shun Zhang, Yan Zhao, Shuyuan Wang, Min Li, Yue Xu, Jianhua Ran, Xiaoqiang Geng, Jinzhao He, Jia Meng, Guangying Shao, Hong Zhou, Zemei Ge, Guangping
NLRP3 inflammasome inhibition attenuates sepsis-induced platelet activation and prevents multi-organ injury in cecal-ligation puncture
Tuesday, June 23rd, 2020
Denise C. Cornelius, Olivia K. Travis, Robert W. Tramel, Marivee Borges-Rodriguez, Cedar H. Baik,Mallory Greer, Chelsea A. Giachelli, Geilda A. Tardo, Jan M. Williams “NLRP3
The urea transporter UT-A1 plays a predominant role in a urea-dependent urine-concentrating mechanism
Wednesday, June 3rd, 2020
Xiaoqiang Geng, Shun Zhang, Jinzhao He, Ang Ma, Yingjie Li, Min Li, Hong Zhou, Guangping Chen, and Baoxue Yang, “The urea transporter UT-A1 plays a
Revisiting Experimental Models of Diabetic Nephropathy
Tuesday, June 2nd, 2020
Anna Giralt-López, Mireia Molina-Van den Bosch, Ander Vergara, Clara García-Carro, Daniel Seron, Conxita Jacobs-Cachá, and Maria José Soler, “Revisiting Experimental Models of Diabetic Nephropathy,” International
Crystal Clots as Therapeutic Target in Cholesterol Crystal Embolism
Wednesday, May 27th, 2020
Chongxu Shi, Tehyung Kim, Stefanie Steiger, Shrikant R. Mulay, Barbara M. Klinkhammer, Tobias Bäuerle, Maria Elena Melica4,5, Paola Romagnani, Diana Möckel, Maike Baues, Elmina Mammadova-Bach,
Metformin Inhibits Cyst Growth and Alters Cell Metabolism in Vitro and Improves Relevant Disease Parameters in a Hypomorphic ADPKD Mouse Model
Friday, May 22nd, 2020
Hui Li, Pei-Yin Ho, Valeria Mancino, Jessica Pham, Saman Sepehr, Biagio Saitta, Nuria M. Pastor-Soler, Kenneth R. Hallows, “Metformin Inhibits Cyst Growth and Alters Cell
Soluble (pro)renin receptor treats metabolic syndrome in mice with diet-induced obesity via interaction with PPARγ
Wednesday, April 15th, 2020
Fei Wang, Renfei Luo, Chang-Jiang Zou, Shiying Xie, Kexin Peng, Long Zhao, Kevin T. Yang, Chuanming Xu, and Tianxin Yang, “Soluble (pro)renin receptor treats metabolic
Targeted Inhibition of Gut Microbial TMAO Production Reduces Renal Tubulointerstitial Fibrosis and Functional Impairment in a Murine Model of Chronic Kidney Disease
Wednesday, April 8th, 2020
Nilaksh Gupta, Jennifer A. Buffa, Adam B. Roberts, Naseer Sangwan, Sarah M. Skye, Lin Li, Karen J. Ho, John Varga, Joseph A. DiDonato, W.H. Wilson
Intracellular Reactive Oxygen Species Mediate the Therapeutic Effect of Induced Pluripotent Stem Cells for Acute Kidney Injury
Wednesday, April 8th, 2020
Shun Wang, Xiaoyu Tian, Yijun Li, Rong Xue, Haochen Guan, Meng Lu, Huijun Xu, Zhibin Ye, Sifeng Chen, and Meng Xiang, “Intracellular Reactive Oxygen Species
Altered renal hemodynamics is associated with glomerular lipid accumulation in obese Dahl salt-sensitive leptin receptor mutant rats
Wednesday, February 26th, 2020
Kasi C McPherson, Corbin A. Shields, Bibek Poudel, Ashley C. Johnson, Lateia Taylor, Cassandra Stubbs, Alyssa Nichols, Denise C. Cornelius, Michael R Garrett, and Jan
α2A-Adrenoceptors Modulate Renal Sympathetic Neurotransmission and Protect against Hypertensive Kidney Disease
Wednesday, February 26th, 2020
Lydia Hering, Masudur Rahman, Henning Hoch, Lajos Markó, Guang Yang, Annika Reil, Mina Yakoub, Vikram Gupta, Sebastian A. Potthoff, Oliver Vonend, Donna L. Ralph, Susan
Hemopexin deficiency promotes acute kidney injury in sickle cell disease
Tuesday, February 18th, 2020
Solomon Ofori-Acquah, Rimi Hazra, Oluwaseun O Orikogbo, Danielle Crosby, Bethany Flage, Ezekiel Bonwin Ackah, Diane Lenhart, Roderick J Tan, Dario A Vitturi, Vivian Paintsil, Ellis
The acute kidney injury to chronic kidney disease transition in a mouse model of acute cardiorenal syndrome emphasizes the role of inflammation
Tuesday, January 28th, 2020
Katsuyuki Matsushita, Turgay Saritas, Mahaba B. Eiwaz, Nicholas McClellan, Ian Coe, Wenbin Zhu, Mohammed Z. Ferdaus, Lynn Y. Sakai, James A. McCormick, Michael P. Hutchens,
Capillary rarefaction is more closely associated with CKD progression after cisplatin, rhabdomyolysis, and ischemia reperfusion-induced AKI than renal fibrosis
Sunday, January 26th, 2020
Anna Menshikh, Lauren Scarfe, Rachel Delgado, Charlene Finney, Yuantee Zhu, Haichun Yang, and Mark P de Caestecker, “Capillary rarefaction is more closely associated with CKD
Cell-free hemoglobin augments acute kidney injury during experimental sepsis
Saturday, January 25th, 2020
Ciara M. Shaver*, Melinda G. Paul, Nathan D. Putz, Stuart R. Landstreet, Jamie L. Kuck, Lauren Scarfe, Nataliya I. Skrypnyk, Haichun Yang, Fiona E Harrison,
Chronic effects of repeated low dose cisplatin treatment in mouse kidneys and renal tubular cells
Friday, January 24th, 2020
Ying Fu, Juan Cai, Fanghua Li, Zhiwen Liu, Shaoqun Shu, Ying Wang, Yuxue Liu, Chengyuan Tang, and Zheng Dong, “Chronic effects of repeated low dose
Disruption of CUL3-mediated ubiquitination causes proximal tubule injury and kidney fibrosis
Friday, January 17th, 2020
Turgay Saritas, Catherina A. Cuevas, Mohammed Z. Ferdaus, Christoph Kuppe, Rafael Kramann, Marcus J. Moeller, Jürgen Floege, Jeffrey D. Singer, James A. McCormick, “Disruption of
Murine models of renal ischaemia reperfusion injury: An opportunity for refinement using non-invasive monitoring methods
Friday, December 27th, 2019
Rachel Harwood, Joshua Bridge, Lorenzo Ressel, Lauren Scarfe, Jack Sharkey, Gabriella Czanner, Marta Garcia-Fiñana, Philip Kalra, Aghogho Odudu, Simon Kenny, Bettina Wilm, Patricia Murray, “Murine
A Novel Model of Chronic Kidney Disease in Rats: Dietary Adenine in Combination with Unilateral Nephrectomy
Monday, December 23rd, 2019
Cristina Muñoz Abellán, Sandra Mangold-Gehring, Sina Micus, Gerald Beddies, Andreas Moritz, Elke Hartmann, Waldemar Lehmann, Frank Eitner, “A Novel Model of Chronic Kidney Disease in
Patrolling monocytes promote the pathogenesis of early lupus-like glomerulonephritis
Friday, December 20th, 2019
Jeeba Kuriakose, Vanessa Redecke, Cliff Guy, Jingran Zhou, Ruiqiong Wu, Sirish K. Ippagunta, Heather Tillman, Patrick D. Walker, Peter Vogel, and Hans Häcker, “Patrolling monocytes
Proximal Tubule-Specific Deletion of the NHE3 (Na+/H+ Exchanger 3) in the Kidney Attenuates Ang II (Angiotensin II)-Induced Hypertension in Mice
Thursday, December 19th, 2019
Xiao C. Li, Dongmin Zhu, Xu Chen, Xiaowen Zheng, Chunling Zhao, Jianfeng Zhang, Manoocher Soleimani, Isabelle Rubera, Michel Tauc, Xinchun Zhou, Jia L. Zhuo, “Proximal
Podocyte-Specific Sialylation-Deficient Mice Serve as a Model for Human FSGS
Thursday, December 19th, 2019
Kristina M. Niculovic, Linda Blume, Henri Wedekind, Elina Kats, Iris Albers, Stephanie Groos, Markus Abeln, Jessica Schmitz, Esther Beuke, Jan H. Bräsen, Anette Melk, Mario
Prenatal Sildenafil Therapy Improves Cardiovascular Function in Fetal Growth Restricted Offspring of Dahl Salt-Sensitive Rats
Tuesday, December 17th, 2019
Fieke Terstappen, Frank T. Spradley, Bhavisha A. Bakrania, Sinéad M. Clarke, Jaap A. Joles, Nina D. Paauw, Michael R. Garrett, A. Titia Lely, Jennifer M.
Restricted Access Matching Human Unilateral AKI, a Reverse Translational Approach to Investigate Kidney Recovery after Ischemia
Friday, December 13th, 2019
Danielle E. Soranno, Hyo-Wook Gil, Lara Kirkbride-Romeo, Christopher Altmann, John R. Montford, Haichun Yang, Ani Levine, Jane Buchanan and Sarah Faubel, “Restricted Access Matching Human
Time-course of sodium transport along the nephron in nephrotic syndrome: The role of potassium
Saturday, December 7th, 2019
Eva Dizin, Valérie Olivier, Charline Maire1, Olga Komarynets, Ali Sassi, Isabelle Roth, Johannes Loffing, Sophie de Seigneux, Marc Maillard, Joseph M. Rutkowski, Aurélie Edwards, Eric
The Absence of the ACE N-Domain Decreases Renal Inflammation and Facilitates Sodium Excretion during Diabetic Kidney Disease
Tuesday, December 3rd, 2019
Masahiro Eriguchi, Ellen A. Bernstein, Luciana C. Veiras, Zakir Khan, Duo Yao Cao, Sebastien Fuchs, Alicia A. McDonough, Jorge E. Toblli, Romer A. Gonzalez-Villalobos, Kenneth
Anti-Transforming Growth Factor β IgG Elicits a Dual Effect on Calcium Oxalate Crystallization and Progressive Nephrocalcinosis-Related Chronic Kidney Disease
Thursday, November 28th, 2019
Stefanie Steiger, Julia Felicitas Grill, Qiuyue Ma, Tobias Bäuerle, Jutta Jordan, Michaela Smolle, Claudia Böhland, Maciej Lech and Hans-Joachim Anders, “Anti-Transforming Growth Factor β IgG
AT1-AA (Angiotensin II Type 1 Receptor Agonistic Autoantibody) Blockade Prevents Preeclamptic Symptoms in Placental Ischemic Rats
Wednesday, November 27th, 2019
Cunningham MW Jr, Castillo J, Ibrahim T, Cornelius DC, Campbell N, Amaral L, Vaka VR, Usry N, Williams JM, LaMarca B, “ AT1-AA (Angiotensin II
Compensatory mechanisms for methylglyoxal detoxification in experimental & clinical diabetes
Tuesday, November 26th, 2019
Dagmar Schumacher, Jakob Morgenstern, Yoko Oguchi, Nadine Volk, Stefan Kopf, Jan Benedikt Groener, Peter Paul Nawroth, Thomas Fleming, Marc Freichel, “Compensatory mechanisms for methylglyoxal detoxification
De novo NAD+ synthesis enhances mitochondrial function and improves health
Sunday, November 24th, 2019
Katsyuba E, Mottis A, Zietak M, De Franco F, van der Velpen V, Gariani K, Ryu D, Cialabrini L, Matilainen O, Liscio P, Giacchè N,
Divergent effects of AKI to CKD models on inflammation and fibrosis
Friday, November 22nd, 2019
Laurence Black, Jeremie M Lever, Amie M. Traylor, Bo Chen, Zhengqin Yang, Stephanie Esman, Yanlin Jiang, Gary Cutter, Ravindra Boddu, James George, and Anupam Agarwal,
The elevation of circulating fibroblast growth factor 23 without kidney disease does not increase cardiovascular disease risk
Thursday, November 21st, 2019
Eva-Maria Pastor-Arroyo, Nicole Gehring, Christiane Krudewig, Sarah Costantino, Carla Bettoni, Thomas Knöpfel, Sibylle Sabrautzki, Bettina Lorenz-Depiereux, Johanne Pastor, Tim M. Strom, Martin Hrabě de Angelis,
Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury
Wednesday, November 20th, 2019
Elena Lazzeri, Maria Lucia Angelotti, Anna Peired, Carolina Conte, Julian A. Marschner, Laura Maggi, Benedetta Mazzinghi, Duccio Lombardi, Maria Elena Melica, Sara Nardi, Elisa Ronconi,
Erythropoietin induces bone marrow and plasma fibroblast growth factor 23 during acute kidney injury
Sunday, November 17th, 2019
Abdulmahdi W, Rabadi MM, Jules E, Marghani Y, Marji N, Leung J, Zhang FF, Siani A, Siskind T, Vedovino K, Chowdhury N, Sekulic M, Ratliff
Kidney dysfunction in the low birth weight murine adult: implications of oxidative stress
Monday, November 11th, 2019
Toro L, Barrientos V, León P, Rojas M, Gonzalez M, González-Ibáñez A, Illanes S, Sugikawa K, Abarzúa N, Bascuñán C, Arcos K, Fuentealba C, Tong
Losartan improves renal function and pathology in obese ZSF-1 rats
Friday, November 8th, 2019
Zhi Su, Deborah Widomski, Artur Nikkel, Laura Lets, Marian Namovic, Diana Donnelly-Roberts, Murall Gopalakrishnan, Steve McGaraughty, “Losartan improves renal function and pathology in obese ZSF-1
Short-term oral gavage administration of adenine induces a model of fibrotic kidney disease in rats
Monday, October 28th, 2019
Chang Z. Zhu, Kelly J. Doyle, Arthur L. Nikkel, Lauren Olsen, Marian T. Namovic, Katherine Salte, Deborah Widomski, Zhi Su, Diana L. Donnelly-Roberts, Murali M.
Ubiquitin C-Terminal Hydrolase L1 is required for regulated protein degradation through the ubiquitin proteasome system in kidney
Sunday, October 27th, 2019
Victoria Rado, Maire Czesla, Julia Reichelt, Julia Fehlert, Anna Hammel, Alva Rosendahl, Jan-Hendrik Knop, Thorsten Wiech, Ulrich O. Wenzel, Marlies Sachs, Anna T. Reinicke, Rolf
Circulating cathepsin-S levels correlate with GFR decline and sTNFR1 and sTNFR2 levels in mice and humans
Tuesday, October 22nd, 2019
Dominik Steubl, Santhosh V. Kumar, Maia Tato, Shrikant R. Mulay, Anders Larsson, Lars Lind, Ulf Risérus, Lutz Renders, Uwe Heemann, Axel C. Carlsson, Johan Ärnlöv,
Combining new tools to assess renal function and morphology: a holistic approach to study the effects of aging and a congenital nephron deficit
Sunday, October 20th, 2019
Stefania Geraci, Jorge Chacón-Caldera, Luise Anne Cullen-McEwen, Lothar R Schad, Carsten Sticht, Victor G Puelles, John F Bertram, Norbert Gretz, “Combining new tools to assess
Exposure to placental ischemia impairs postpartum maternal renal and cardiac function in rats
Thursday, October 17th, 2019
Nina D. Paauw, Jaap A Joles, Frank T. Spradley, Bhavisha Bakrania, Zsuzsanna K Zellenger, Arie Franx, Marianne C. Verhaar, Joey P. Granger, A. Titia Lely,
Human Kidney-Derived Cells Ameliorate Acute Kidney Injury Without Engrafting into Renal Tissue
Tuesday, October 15th, 2019
Ilaria Santeramo, Zeneida Herrera Perez, Ana Illera, Arthur Taylor, Simon Kenny, Patricia Murray, Bettina Wilm, Norbert Gretz, “Human Kidney-Derived Cells Ameliorate Acute Kidney Injury Without
An integrin antagonist (MK-0429) decreases proteinuria and renal fibrosis in the ZSF1 rat diabetic nephropathy model
Sunday, October 13th, 2019
Xiaoyan Zhou, Ji Zhang, Robin Haimbach, Wei Zhu, Rosemary Mayer-Ezell, Margarita Garcia-Calvo, Elizabeth Smith, Olga Price, Yanquig Kan, Emanuel Zycband, Yonghua Zhu, Maarten Hoek, Jason
Long-Term Endothelin-A Receptor Antagonism Provides Robust Renal Protection in Humanized Sickle Cell Disease Mice
Wednesday, October 9th, 2019
Kasztan M, Fox BM, Speed JS, De Miguel C, Gohar EY, Townes TM, Cutler A, Pollack DM, “Long-Term Endothelin-A Receptor Antagonism Provides Robust Renal Protection
Low birth weight is associated with impaired murine kidney development and function
Tuesday, October 8th, 2019
Christina Barnett, Oluwadara Nnoli, Wasan Abdulmahdi, Lauren Nesi, Michael Shen, Joseph A Zullo, David L Payne, Tala Azar, Parth Dwivedi, Kunzah Syed, Jonathan Gromis, Mark
Renal Tubular ACE-Mediated Tubular Injury is The Major Contributor to Microalbuminuria in Early Diabetic Nephropathy
Friday, October 4th, 2019
Masahiro Eriguchi, Mercury Lin, Michifumi Yamashita, Tuantuan V. Zhao, Zakir Khan, Ellen A. Bernstein, Susan B Gurley, Romer A. Gonzalez-Villalobos, Kenneth E. Bernstein, Jorge Fernando
Targeted mitochondrial therapy using MitoQ shows equivalent renoprotection to angiotensin converting enzyme inhibition but no combined synergy in diabetes
Tuesday, October 1st, 2019
Micheal S. Ward, Nicole B. Flemming, Linda A. Gallo, Amelia K. Fotheringham, Domenica A. McCarthy, Aowen Zhuang, Peter H. Tang, Danielle J. Borg1, Hannah Shaw,
Transcutaneous Glomerular Filtration Rate Measurement in a Canine Animal Model of Chronic Kidney Disease
Monday, September 30th, 2019
Thomas Mondritzki, Sarah M.L. Steinbach, Philip Boehmea, Jessica Hoffmann, Maximilian Kullmann, Daniel Schock-Kusch, Julia Vogel, Peter Kolkhof, Peter Sandner, Erwin Bischoff, Jörg Hüser, Wilfried Dinh,
Chronic recurrent dehydration associated with periodic water intake exacerbates hypertension and promotes renal damage in male spontaneously hypertensive rats
Wednesday, September 25th, 2019
Hilliard LM, Colafella KM, Bulmer LL, Puelles VG, Singh RR, Ow CP, Gaspari T, Drummond GR, Evans RG, Vinh A, Denton KM, “Chronic recurrent dehydration
Intestinal Dysbiosis, Barrier Dysfunction, and Bacterial Translocation Account for CKD-Related Systemic Inflammation
Saturday, September 21st, 2019
Andersen K, Kesper MS, Marschner JA, Konrad L, Ryu M, Kumar Vr S, Kulkarni OP, Mulay SR, Romoli S, Demleitner J, Schiller P, Dietrich A,
Maternal glucose intolerance reduces offspring nephron endowment and increases glomerular volume in adult offspring
Monday, September 16th, 2019
Hokke S., Arias N., Armitage J.A., Puelles V.G., Fong K., Geraci S., Gretz N., Bertram J.F., Cullen-McEwen L.A., “Maternal glucose intolerance reduces offspring nephron endowment
Maternal Glucose Intolerance Reduces Offspring Nephron Endowment and Increases Glomerular Volume in Adult Offspring
Saturday, September 14th, 2019
Hokke S, Arias N, Armitage JA, Puelles VG, Fong K, Geraci S, Gretz N, Bertram JF, Cullen-McEwen LA, “Maternal Glucose Intolerance Reduces Offspring Nephron Endowment
